1798年吳瑭著《溫病條辨》首創安宮牛黃丸。其后同仁堂開始生產安宮牛黃丸。1870年樂十世樂平泉修訂《同仁堂傳統配本》，首列瘟疫門，安宮牛黃丸是瘟疫門首藥。
Angong Niuhuang Pills were invented by Wu Tang and documented in his work Wenbingtiaobian in 1798, and Tong Ren Tang began to produce Angong Niuhuang Pills thereafter. In 1870, Le Pingquan, the tenth generation of the Le family, firstly included the category of epidemic diseases in his amendment to the Tong Ren Tang Traditional Chinese Medicine Prescription and considered the Angong Niuhuang Pills as the preferred medicine for this category.
同仁堂安宮牛黃丸有文字記載的傳承至今149年。在百余年中，同仁堂將自身的制藥工藝和清宮御藥房制藥標準、傳統中醫藥文化和中華文化有機結合，形成了安宮牛黃丸傳統制作技藝。
Tong Ren Tang Angong Niuhuang Pills have a documented history of 149 years. Through over a hundred years of development, Tong Ren Tang integrated its owned medicine production techniques with the medicine production standards for the imperial family of Qing Dynasty, traditional Chinese medicine culture and Chinese culture, forming its owned traditional production techniques of Angong Nihuang Pills.
